- Proteomics
- Olink Proximity Extension Assay
- Hormones and small molecules
- LC-MS/MS
- HbA1c
- HPLC, for variant resolution
- Sequencing
- Illumina NovaSeq X Plus, for clinical exome and cfDNA methylation
- Methylation
- Illumina methylation arrays, for DunedinPACE
Validation
Every assay is validated through Karolinska Bridging Protocols, which establish clinical equivalence between the finger-prick microsample and matched venous blood. The PrecisionIndex team works with Professor Nadir Kadri, and the study runs under ethical approval at Karolinska Institutet.
The system is being clinically validated in a multi-centre study across UK, EU and UAE cohorts. Initial peer-reviewed publications are in preparation.
Regulation
Precision 360 is clinical decision support, not a diagnostic device. The clinician keeps full clinical judgement. This positioning has been confirmed with regulatory counsel under the MHRA and EU MDR/IVDR frameworks.
What a microsample can't do
Cortisol rhythm needs several timed samples, 24-hour urine collections can't be replicated, and some specialised metabolomics and rare hormone assays still need a venous tube. For those, your standard pathology pathway remains the right tool.